Re-analysis of the studies after their categorization into autoantibody-dependent and T cell-dependent autoimmune diseases revealed that the HLA-DRB1*16:02 allele was strongly associated with disorder predominantly mediated by autoantibodies (OR = 1.93 95% CI = 1.63–2.28, P = 1.95 × 10 −14) but not with those predominantly mediated by T cells (OR = 1.08 95% CI = 0.87–1.34, P = .474). However, no such association was found for multiple sclerosis, autoimmune hepatitis type 1, rheumatoid arthritis, type 1 diabetes and Vogt-Koyanagi-Harada syndrome. Our analysis shows that HLA-DRB1*16:02 allele was associated with systemic lupus erythematosus, anti-N-Methyl- d -Aspartate receptor (NMDAR) encephalitis, Graves' disease, myasthenia gravis, neuromyelitis optica and antibody-associated systemic vasculitis with microscopic polyangiitis (AASV-MPA). In this study, we performed a meta-analysis of the association between HLA-DRB1*16:02 allele with various autoimmune disorders. However, a validation of the results of the different studies by a comprehensive analysis of the corresponding meta data is lacking. The human leukocytes antigen (HLA)-DRB1*16:02 allele has been suggested to be associated with many autoimmune diseases.
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